How to Balance Autophagy and mTOR for Longevity and Muscle Growth. While discussing protein degradation above, it is worth noting that SIRT6 has been associated with modulating lifespan via nuclear factor κB (NF-K β) signalling (Yeung et al., 2004; Kanfi et al., 2012b). TUESDAY, March 18, 2014 (HealthDay News) -- The more muscle older adults have, the lower their risk of death, according to a new study. From what little I know, it seems that lower consumption of amino acids and in particular leucine correlate with a longer lifespan. The final conclusion would be that for health and longevity, you want to balance catabolic autophagy with anabolic mTOR and muscle growth. By Robert Preidt. Does building muscle from working out go against longevity? Sirtuins and NF-K β and their roles in longevity and skeletal muscle loss with age. A new study finds endurance exercise boosts the growth of vital muscle stem cells and sets off a cascade of regenerative effects on the body. longevity hacks. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. Muscle and fat are two highly metabolic tissues. The importance of muscle for health, happiness and longevity. I like working out and taking whey protein supplements and trying to get a caloric surplus to gain muscle mass. The importance of muscle for health and longevity is rarely appreciated. It can literally be a matter of life or death. How our tissues interact with our metabolic machinery matters. Muscle mass is associated with longevity. I have written before about how to preserve muscle mass in order to age gracefully, but here I go into more detail on why it is important. “Maintaining muscle strength throughout life - and especially in later life - is extremely important for longevity and ageing independently,” said lead researcher Kate Duchowny. Muscle mass gradually declines as part of the aging process—called sarcopenia, it’s considered one of the largest risks for loss of function, mobility, and independence for older adults. HealthDay Reporter. Too much of one or the other isn’t ideal and has some negative side-effects.